dopamine-serotonin interaction hypothesis

n. The theory that dopaminergic pathways are primarily involved in the positive symptoms of schizophrenia while serotonergic pathways are primarily involved in the negative symptoms. This is supported by findings that drugs which reduce both dopamine and serotonin activity are better at relieving both positive and negative symptoms of schizophrenia and are also associated with more normal electroencephalographic patterns in the brain than are dopaminergic drugs alone.